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Why I No Longer Recommend Prescript Assist (And What I’m Using Instead)

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prescript assist probiotic review

I’ve been recommending spore-based probiotics for years and giving them to my own family. Prescript Assist was one of my top choices because it was clinically validated and several practitioners I deeply respect reported good results with it. However, it was reformulated in 2017 and – although I usually go by the adage that if you can’t say something positive not to say anything at all – I feel it is important to update you about why. Here are my concerns:

1. Limited or no evidence of benefit for the reformulated version – Of the 29 strains used in Prescript Assist’s original formula that was shown to be helpful for Irritable Bowel Syndrome in randomized, controlled clinical trials, only nine are used in the new formula. Of the nineteen new strains are included, most have no or very little clinical evidence supporting their use.

2. Undeclared allergens – In 2018, Magnetic Clay (now Enviromedica) issued a voluntary recall after they learned that their supplier violated Good Manufacturing Practices (GMP), resulting in the presence of undeclared allergens including almonds, crustaceans, milk, casein, eggs, and peanuts.

Magnetic Clay urged consumers to return the product to them for a full refund, which I respect immensely. Many companies don’t issue recalls for known problems because they don’t want to offer reimbursements, but Magnetic Clay chose to do the right thing.

What I’m Using Instead

Right now I’m using Just Thrive probiotics. In addition to using clinically validated strains, Just Thrive is manufactured in a Certified Good Manufacturing Practice (cGMP) facility, which is the gold standard for quality and purity.

Just Thrive probiotics are unique in a couple of ways:

  • 100% survivability – Unlike many strains which don’t fare well when exposed to stomach acid, Just Thrive probiotics have been proven to arrive in the intestines 100% alive
  • It makes antioxidants and vitamins in the gut– Just Thrive contains a strain called Bacillus Indicus HU36®, which produces antioxidants/ carotenoids (the nutrients that give red peppers and tomatoes their color) inside your gut, making it one of the most absorbable forms of antioxidants available. HU36 also produces B vitamins and Vitamin K2.

There are other benefits, too. In addition to HU36, Just Thrive contains three other research-backed strains that aid digestion, support healthy bowels, and provide powerful immune support.

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433 Comments

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  1. My children (ages 1 and 3) haven’t tried swallowing capsules yet, but I believe both would benefit from a product like this. It would be interesting to try! Thanks for the opportunity.

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    • I really think this is something I need! I have had issues all my life and have been told that I have a leaky gut. Going to print out information and take it to my Naturopathic Physician so he can see about this great product.

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      • I have had leaky gut for over 13 years and have improved tremendously from doing the microbiota transplant with a friend! Nothing has improved my condition as much as this. Make sure your research also included info re: lectins and phytates. Took me for ever to find this much information. What you find is cutting out the gluten is replace with Brown Rice flour however, this also attaches to the gut wall doing harm. You have to cut out grains but get a list of lectins and phytates.

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    • Me too! My boyfriend and I have been easing our way into GAPS for a few months because he has no health insurance and some terrible stomach problems. We haven’t really noticed a difference with the refrigerated kind we find at places like Whole Foods, so maybe this is what we need!

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  7. I have been curious about Prescript-Assist, but neither my Whole Foods nor co-op carry it. Actually, a lot of the supplements I wanted were not there. I’m really working to heal my digestion/adrenal/hormonal function. Thanks for offering the giveaway!

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    • I havent tried this product but I’ve found using a D-lactate free probiotic has done wonders for my son with autism. Antioxidants such as vit D and NAC reduce his stimming impulses. Methyl-folate, magnesium and methyl-b12 (injection in his sleep every 3rd night) make a difference too. When I stopped the injections the family members who had been very against me giving him an injection all said that he needed to go back on it since they could see now that they made a big difference. I’m not a doctor and I’m not promoting any products I just thought I’d share my experience. I love my sons quirks, but I’m happy to have found a few things to detoxify him and reduce symptoms that are uncomfortable for those around him, but most importantly him. He’s done so well that his Kindergarten teacher isn’t even requesting aide support for him when he had a year of funding left over! I contibute at least part of his ability to succeed to these safe biomed supplements. On occasion he gets a digestive enzyme and we did remove gluten, dairy, eggs, and soy from his diet but after a year we allow them on occasion mostly because it helps us focus on nutritious foods such as almond/cashew products, ancient grains, non GMO starches such as potato and corn as well as magnesium rich nuts. All the best!

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    • I havent tried this product but I’ve found using a Custom Probiotics D-lactate free probiotic has done wonders for my son with autism. Antioxidants such as vit D and NAC reduce his stimming impulses. Methyl-folate, magnesium and methyl-b12 (injection in his sleep every 3rd night) make a difference too. When I stopped the injections the family members who had been very against me giving him an injection all said that he needed to go back on it since they could see now that they made a big difference. I’m not a doctor and I’m not promoting any products I just thought I’d share my experience. I love my sons quirks, but I’m happy to have found a few things to detoxify him and reduce symptoms that are uncomfortable for those around him, but most importantly him. He’s done so well that his Kindergarten teacher isn’t even requesting aide support for him when he had a year of funding left over! I contibute at least part of his ability to succeed to these safe biomed supplements. On occasion he gets a digestive enzyme and we did remove gluten, dairy, eggs, and soy from his diet but after a year we allow them on occasion mostly because it helps us focus on nutritious foods such as almond/cashew products, ancient grains, non GMO starches such as potato and corn as well as magnesium rich nuts. All the best!

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  26. I’ve been battling candida for 13 years and the probiotic costs have really added up! I’ve never tried this brand before. I’d love to give it a try! Thank you for the giveaway! 🙂

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  30. It would be such a blessing to be able to try these. I suspect my family and I are struggling with Candida or Leaky Gut. I was just recently diagnosed with an autoimmune thyroid issue plus an inability to absorb certain B vitamins. The remedies have been really costly so a chance to try this as a gift would mean the world to us!

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  35. I’m in the Nutritional Therapy Practitioner program and when working with my practice clients I am always recommending a probiotic along with other digestive support. I have been recommending a couple of other brands, but recently heard from Chris Kresser and YOU 🙂 that these are the most effective at colonizing and resulting in more healing. Since you guys are smarter than I am, I am dying to try them to see if I also can recommend when I start my practice!

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  40. I really, really, really need this so bad. I have suffered with severe digestive issues for years. They are so bad I have this unnerving fluttering in my chest. I have had a complete cardiac work up and found no issues. I KNOW it is stomach related because I have the most issues when I feel gassy or like my food is undigested for hours. I have been diagnosed with IBS with constipation but I know there is something more than that going on. My sister suffers from the same issues and she was diagnosed with gastroparesis. Would be a blessing to win and give this a try!

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    • From the year 1997- 2010 I was under the impression I had IBS…I was even diagnosed by a “Specialist in the late 90’s who confirmed this impression. The symptoms were severe enough that I had to retire as school bus driver 🙁
      In March of 2010 I was in n the hospital with very painful spasms in my belly/abdomen.
      Tests such as a vaginal ultrasound revealed a twisted colon. Emergency surgery was performed that evening to temporarily in untwist the colon and get my system thoroughly cleaned out before performing the major surgery to remove 3 feet of my colon. I could have died if it had burst! I owe my life to Jesus, and my adult daughter, whose threat that she’d never speak to me ever again, if I didn’t get to the emergency room!
      I pray you received thorough tests! God bless you!

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  53. I’ve been taking Dr. Mercola’s probiotic and haven’t been sick (like a cold/virus) my entire pregnancy! I’ll definitely look into these as I am not brand loyal and a beginner.

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  68. ID LOVE TO GIVE THESE A TRY. WITH MY FAMILY NOT HAVING AN INCOME RIGHT NOW WE WOULD LOVE TO WIN THE GIVEAWAY SO WE CAN STAY HEALTHY WITHOUT THE MONEY RIGHT NOW. THANK YOU FOR THE OPPORTUNITY!!

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  69. I would love to win because I am pregnant and we have a toddler…ever since my toddler was a baby and “got an ear infection” we’ve been using probiotics. I fell for that whole doctor bit and used an antibiotic and she had been sick ever since…she has hardly been sick in 2 years since starting probiotics! This would be great to help out with the expenses since it seems we are always buying FCLO, probiotics, or something! 🙂

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  83. I’d love to win I have such a bad stomach/digestive system! I’ve lost my gallbladder and appendix and have been so inflamed/pain since and it’s been 3yrs! Thanks for the giveaway 🙂

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  84. My gut was wrecked because of the chemical our water company uses to ‘clean’ the water (chloramine). After 10 years, I am still trying to ‘fix’ it– I have seen a huge improvement since I have started using prescript-assist which was recommended by my GAPS practitioner.

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  89. Im hoping this probiotic can work…because most dont do a thing for me. Plus, I cant eat any fermented foods because of histamine problem, so this will help get in new strains! yeah!!

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  90. I’ve heard of this brand from Chris Kesser. I’m always looking for an effective Probiotic. The last one I tried was Bio-Kult. It’d be great to see how I fare with this one.
    Thanks for a giveaway only health-nuts would love 🙂

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  102. Recently got this for my hubby who has the beginnings of colon issues. Hoping to bolster his flora and intestinal resilience. I’d love to try it too but since it is spendy, him first.

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  103. My 10 yo son is currently on two antibiotics for pneumonia. It’s the first time anyone in our family has taken those nasty drugs in years, and I hate it. He will be drinking kombucha, kefir, and eating lots of yogurt, but he needs all the help he can get!

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  117. Heather, thank you for this Giveaway! What I am curious about is how does this differ from GutPro (which was a past Giveaway)? Do you have a preference for one over the other? Thank you!

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    • Prescript Assist and GUTPro are the two probiotics that I have in my kitchen right now. They’re totally different because GUTPro is a lactic acid-based formula and Prescript Assist is a soil-based formula. I try to eat fermented foods everyday, but when I get behind I supplement with GUTPro. I also try to get outdoors a lot but I take Prescript Assist a couple of times a week because I don’t have a garden or fertile tilth to dig around in 🙂

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  127. I just ordered Prescript Assist from Amazon for my daughter who is having major digestive issues right now. She has had numerous blood tests and we are still waiting to hear results. Her doctor recommended a probiotic, so I began researching right away to find the best one. What a coincidence to see your contest advertised on Facebook. I’m crossing my fingers!

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  128. I’m healing rheumatoid arthritis through diet, and restoring gut balance is a key step in the process. Like you, I make my own fermented foods, but would love to round it out with some SBO’s.

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  133. I’m pretty sure my youngest daughter suffers from leaky gut, and I know myself and the other kids need a little more gut support since we don’t eat fermented foods every day.

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  135. I just ordered the cod liver oil from your other post and I really want to order this too, but being a SAHM we don’t have the extra funds right now. I’m also battling pcos and I’m trying to get my body back into its naturally healthy state now that it’s almost been a year since having my daughter. Thank you for your blog, I’m learning so much!!

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  148. I have taken many rounds of antibiotics through my teens and twenties and unfortunately have needed to take 3 rounds of antibiotics during this pregnancy, which has been very upsetting. I’m sure my G.I. tract could use some serious help. This probiotic sounds wonderful.

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  150. My husband is in desperate need of some gut healing. I’m trying to get to eat more whole foods, but it’s a slow process. This will help tremendously! Thanks for the giveaway!

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  160. Do you take probiotics while you are pregnant? I was told not to take probiotics while I am breastfeeding, because of the toxins that can be potentially produced in my breastmilk? What do you think about that? I do not think I agree.

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  167. So, I just read all about this stuff this morning. I’m sold, I need it now! Only problem is I just convinced my husband that we could afford to buy fermented cod liver oil. So now I have no money for this! lol. I’m a biology student and have worked with some of these microorganisms, and some very similar to the ones here. Needless to say I am very excited to try this product, and this seems like my chance! THANKS!!!!!

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  171. I would love to win this for my daughter and myself. I almost bought it on Perfect Supplements with the Village Green Network membership discount, but I opted to stock up on my Green Pasture’s products instead. I couldn’t afford both. I’d be wonderful to win. 🙂

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  175. My gut SUCKS. I have terrible eczema and digestive issues (food goes in but doesn’t come out…) and the only way I can solve this is through probiotics in some form. I’ve tried fermenting vegetables but mum is an absolute clean freak and hates me leaving out vegetables without the lids properly shut for more than three hours, and we don’t have access to raw milk because it’s banned in Australia. Having probiotics in a pill would make life SOOO much easier, so that my eczema would go away and I wouldn’t feel so bloated all the time!

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  179. i would love to win! I’ve been working to heal my GI for five years now and still have a ways to go. I’d love to try this brand; I’ve mostly used ohhira’s with good results. We’ve not had money recently for probiotics 🙁 so I really want to win this one.

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  182. About to start Whole30 and could really use a good probiotic to help heal my digestive problems, and like so many others, I don’t currently have the money for probiotics in my budget…

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    • They’re totally different. GUTPro is a lactic acid-based formula, whereas Prescript Assist is soil-based. I try to eat fermented foods every day, but when I get behind in my kitchen I take GUTPro. I also try to get outside a lot, but I am still working to establish a garden so I can’t say I’m getting a lot of good microbes from productive soil. For that reason I take Prescript Assist.

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    • It has 145 million CFU per capsule – however, it cannot be compared to CFU’s in lacto and bifido based probiotics where massive numbers are required the majority die during manufacturing, storage, stomach acid, etc, etc.

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  214. Would love this opportunity to try something new. I have been spending a LOT of money on probiotics and it has lead me to a whirlwind of confusion. One day, I will figure it all out.

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  215. Just this past week I HAD to take anti-biotics 🙁 and yesterday I started to look into the best probiotic to start taking to rebuild my gut, and I came across this one, and now today there is a giveaway!! It couldn’t be more fortuitous than that,

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  219. I need to win because my son and I have lots of food allergies. He has autism and we have struggled with his gut balance for years. Keep switching probiotics and don’t see the improvement the price should guarantee 😉
    Can’t tell you how good these sound to me! Yea!

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  224. My son has autism and one of his supplements is quality probiotics. Currently we’ve been using Klaire’s Detox Support, which we love. However, I’ve read it’s important to rotate them, so I’d love to win so he can try these and see how they work for him. High quality probiotics are very important, and it’s clear these are high quality!!

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  231. this is fascinating. I’d really like to try this; I’ve been building up my gut flora with kombucha, milk kefir cheese, homemade kimchee and ginger bugs, but i’m afraid to eat dirt i find outside; there are too many chemicals everywhere. maybe after a few years of building up the soil in my garden… i’ll get more brave. for now i’d love to try this.

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  243. I am on a limited income but have heard so much about pro and prebiotics…have you seen the prices?
    I would love to try these and compare this brands price with others…perhaps they are more reasonable 🙂

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  249. I would like to win these probiotics because I have been wanting to try probiotics for a while now, however I have not been able to determine the best type to take. This looks like a good one, so I would love to win it and start taking it!

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  257. We are gonna try to start having a baby and I want my body to be in tip top shape and I know this will help get it there! The other day when you posted the link about this stuff I seen it and was amazing at how much sense it made! I have kept the tap open for a bottle of it for days. And even tho I know we can’t afford it right now, I kept the tab open to day dream about getting it (I know sad lol) and I have also shared it with friends so anytime I need to copy and post the link for it, it’s there 🙂

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  259. This might be the product that would help heal my gut/heartburn issues. I’ve been taking acid reducers for a few weeks and have 2 more weeks to take them and been wondering what probiotics to take after that. Sounds like a wonderful product that might help me!!

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  260. I have years of digestive troubles that i have been trying to manage with a whole foods diet, I feel better, but i know i need a really super probiotic and i have yet to find one. I also now have a 3 month old baby who seems to fair much better when i do take probiotics. Since i am currently not working and with no mat leave as i work for myself i cant afford these, but this would be a great way to try and then i can purchase once back at work and can afford them 🙂
    I am really hoping this could be an answer to years of trying to heal.

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  270. I’d love to win this probiotic for my son who I just put on the GAPs diet because of dyspraxia. We can’t really afford a good probiotic right now and this would be great to help jumpstart him.

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  276. I would love to win this! Probiotics can be so expensive and not even a really great brand. I have a family of 6 so it is even more expensive to constantly have what we need. This would help me out immensely!

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  284. Thanks, MommyP, for offering another wonderful product as a giveaway! I use Biokult and Florastor, and have been wanting to try Prescript Assist for a while. Thanks for the chance.

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  285. Just finishing my 1st bottle of Prescript Assist and I’m feeling *much* better than I was. Will continue taking it but, it would be nice to be helped out financially by winning your giveaway.

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  291. I read the article in the NYTimes by Michael Pollan–definitely have wanted to eat more dirt since then. My babes (13 months and 4 1/2) both have digestive issues–likely from my sad gut flora. I would love to try this to see if we can improve!

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  297. Since starting GAPS intro last week I’ve been looking into high grade probiotics to speed healing. So good to have your opinion on this one! True medical grade probiotics are hard to find.

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  301. I’m ‘leaving a comment’ for an entry, as I’m very interested in making these a part of our dietary habits. And Thank you for doing all the work & research to bring us this info, and then to offer a giveaway!
    On a different note…I love your giveaways (and even moreso your super informative and entertaining blog posts), but I’m often not sure what to do with some of the entry fields in your giveaway forms. Like the one that says to check out the product’s link above and then there’s an empty box- I assume I should put my e-mail address in it, but I just thought I’d kindly suggest that with a few of those different entry options, there might be more info on what to fill the boxes in with.
    Thank you again! 🙂

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  309. Thank you for the opportunity to try this probiotic! Just visited a holistic dentist for some dental issues with my 7 year old. This, in addition to some other options including those listed by the Weston Price Foundation, could help him.

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  316. These were recommended by a GAPS practitioner who did a talk for our local WAPF group. I’ve been wanting to try them ever since. I suppose if I don’t win I should just prioritize and give them a try. Fermented foods are great but I think my kids and I need a bit of an extra boost.

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  319. I’ve never tried a probiotic supplement before. Plus, my husband isn’t huge on trying to get his probiotics through food, so this would be great for me to be able to give him!! 🙂

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  321. I’ve been dealing with IBS for about 15 years now and the only thing that seems to help is probiotics. I don’t think the probiotics I’m currently taking is as good as this one so I’d really love to try it.

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  346. Lyme Disease here. Probiotics make such a major difference. I’m interested in trying these. I’ve never tried SBO probiotics but I’m a believer that probiotics make a huge difference.

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  351. My friend has a nursing 8 month old who is having a round of antibiotics. She’s dairy sensitive. What’s the best way for baby girl to get some good probiotics in her system? If mom took these, would the benefits pass to baby? could a capsule be sprinkled on some pureed food?

    Thanks!

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  371. I’m trying my best to increase my gut flora! I’ve struggled with mild tummy troubles and GI issues over the years – probably due to the vast amount of antibiotics taken in the past. I’d love to try this out!

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  374. My girls have just started going to a new doctor who has prescribed they get started on a probiotic. They of course suggested another brand that is easily found at pretty much any grocery store…I’d rather use and pay for something that’s gonna do us some good!

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  376. I would like to win the probiotic because 1.) we just ran out of probiotic and 2.) my husband has had IBS and we have changed to a real food diet, but would love to continue the use of probiotics!

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  382. I’d like to win these probiotics because I desperately need to get my gut flora back in shape…I’ve not used probiotics before and most of the good ones are really expensive…would love to not break the budget trying these. If they work…I might just be able to get my husband to take them, too. I think his gut flora needs more help than mine…

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  393. what easier way to try something new. We’ve done probiotics before, but haven’t been consistent- didn’t notice positive results. Perhaps this different formula will work better!

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  394. I am just beginning my real food journey and would love to defray some of the “startup costs” so my hubby doesn’t want to wring my neck! Also I am a huge probiotics food girl. My tummy and intestine seem to be a week point for me.

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  397. I was wondering if these are safe for children, and if so is the dosage the same? I’ve tried searching, but can’t seem to find that anywhere. I did see on Prescript Assist’s site that they are “for adults.” Just wondered if you knew. Thanks!

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  399. Heather, I am interested in trying this probiotic for my 3 year old. I am trying to feed him and supplement in ways that will boost his immune system. My question is that I have also read there may be concerns about SBO’s being pathogenic and ” taking over” the gut including the good bacteria housed there. Do you have any thoughts on these ideas? Thanks. I love your blog and respect your opinions.

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    • Hi April, first off I would like to say that I am not a healthcare professional and cannot give advice regarding specific situations. Personally, after looking at the research I’ve concluded that there is a huge difference between endospore forming organisms and “spore forming” organisms. Prescript Assist contains only endospore forming organisms, which according to the manufacturer are inactive in the body. They wait until they are expelled to do their thing.

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  402. I was wondering if this was ok to take while pregnant? I have currently been taking a different brand of pre/probiotics and it’s almost gone. I’d like to switch to something more organic/natural. I read about another brand that causes serious diarrhea for a few days and didn’t want something that “violent”. I was hoping to find something a little more gentle. Thank you!

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  403. This is a wonderful product. We are now using this in our home. Though I do have a question for all of you – have you found a probiotic (that does not need to be refrigerated) that your children like to take? Someone recommended Rainbow Light’s gummies. Any suggestions? Thank you and best wishes all!

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  404. Hi there, may I ask what probiotics you are giving your children? I am looking for something that does not need to be refrigerated. We parents are taking this product, mentioned above, but I am wondering about gummies like Rainbow Lights.
    Thank you and best wishes Mamas!

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  409. Probably a great product and I’d try it for my son who has autism had we not found one that has corrected his gut issues, is d-lactate fee and even though it has a higher upfront cost, it’s a fraction of the cost since it lasts at least 6 months. Plus ours is a powder. I keep the one we have in the fridge but it can remain at room temperature for up to 2 weeks while maintaining 260B /g on date of expiry. I don’t want to appear like I’m promoting any brand but if you google d-lactate free probiotic it should come up. It’s also ships to Canada!

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    • That’s a great question, but unfortunately there’s no one definitive answer. Some people say they are totally fine and even beneficial during pregnancy/lactation, while others say they’re not. Like most probiotics and other supplements, the label simply says to consult a physician before taking them if you are pregnant or breastfeeding. My takeaway from that is that the answer depends on a persons individual situation and health needs, and that a conversation with a practitioner is best for determining what’s appropriate.

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  411. I am not getting paid for this comment, but I wanted everyone to know that I have tried and currently use Just Thrive Probiotics. They have been the best probiotics I have ever tried, and I have tried everything from the generic to name brand. I have never seen any probiotic clear up my skin and help with constipation like this one does. I cannot say whether it helps with leaky gut or not because I have not technically been diagnosed with that, but I have nothing but rave reviews for it. I actually joined their subscription service because I was so impressed. I give it to my children also. Just open a capsule and put it in their water for them to drink. If you have not had any success with a probiotic yet, I highly recommend you try Just Thrive.

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I'm Heather, aka The Mommypotamus. I’m a wife, mom, real food lover, research geek, and amateur homesteader. And potamus... obviously.

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